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Index > Protein center > Stab2(Gene name) > Mouse
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  • Stab2 (Gene name),
  • Stabilin-2 (Protein name ),  STAB2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Stab2(Feel2;Hare);
    Protein name:
    Stabilin-2;
    Alternative:
    Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2(FEEL-2);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with heparin, alpha-M/beta-2 integrin (ITGAM and ITGB2), and thymosin beta 4 (TMSB4X) (By similarity). Interacts with GULP1. Associates with clathrin and adapter protein AP-2; in liver sinusoidal endothelial cells (LSECs).
    Function:
    Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed short form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.
    Subcellular Location:
    Cytoplasm Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    2559
    Sequence:
    50:
    MARSKLLLGK | LLPLILIFLG | LLVQNACSPT | EAPELTKRCD | KKSTLTIKTE | 
    100:
    CQSCSVNIAV | KCPDGYIKIT | NGTVGVRDCR | YSLKIQSYVL | DIPGCRHICR | 
    150:
    KDYLQPQCCP | GHWGPDCMEC | PGGARAPCGG | RGVCDEGMEG | TGSCSCRAGF | 
    200:
    RGTACENCAA | EDVFGPNCSA | VCSCVHGVCN | SGISGDGTCE | CLSAYRGPRC | 
    250:
    DKPIPECAAL | LCPENSRCSP | SSKDETKLQC | KCLPSYKGDG | QTCKPINPCL | 
    300:
    KNVCHPHASC | SYLGPNRHSC | VCQKGYQGDG | QVCLPVDPCQ | TSYGNCPTKS | 
    350:
    TVCRYDGPGQ | SHCECKEHYR | NFVPGVGCSM | TDICESKNPC | HKNANCSTVS | 
    400:
    PGQTQCTCQK | GYVGDGLNCY | GNIMQRLREL | NTEPRGMWQG | QLTSFISILD | 
    450:
    RTYAWPLSNL | GPFTVLLPSD | KGLKGVDVKE | LLMDKEAARY | FVKLHIIAGQ | 
    500:
    MSTEQMYNLD | TFYTLTGKSG | EIINKDKDNQ | LKLKLYGSKI | VQIIQGNIVA | 
    550:
    SNGLVHILDR | AMDKIEPTLE | SNPQQTIMTM | LQPRYGKFRS | LLEKTNVGQA | 
    600:
    LEKGGIDEPY | TIFVPSNEAL | SNMTAGVLDY | LLSPEGSRKL | LELVRYHIVA | 
    650:
    FTQLEVATLV | STLHIRSMAN | QIITFNISSK | GQILANNVAV | DETEVAAKNG | 
    700:
    RIYTLTGVLI | PPSILPILPH | RCNETKREMK | LGTCVRCFMK | NWSKCPTNSE | 
    750:
    PTAIFTNKCF | YGSRAWNLKI | GCARYCDVTV | EIPRCCKGFF | GPDCNPCPGG | 
    800:
    FMNPCSGNGQ | CIDGLGGNGT | CICEDGFQGS | RCQFCSKPNR | YGPQCNRTCQ | 
    850:
    CVHGICDNRL | DSDGSCLPGT | CREGTAGRFC | DKQTSACGPY | MQFCHIHATC | 
    900:
    EYSNETASCV | CNDGYEGDGT | LCSKKDPCLG | STSRGGCSPN | AECIQASTGT | 
    950:
    YSCVCQRGWT | GNGRDCVEIN | SCLLPSSGGC | HDNATCLYVG | PGQNECECKK | 
    1000:
    GFRGNGIDCE | PIISCLEQIE | KCHPLATCQY | TLSGVWSCVC | QEGYEGNGVL | 
    1050:
    CYGNVLMELS | FLSEAAVFYQ | WINNASLQSM | LSATSNLTVL | VPSLQAIKDM | 
    1100:
    DQNEKSFWLS | RNNIPALIKY | HTLLGTYRVA | DLQTLPSSHM | LATSLQGSFL | 
    1150:
    RLDKADGNIT | IEGASFVDGD | NAATNGVVHI | INKVLIPQRG | LTGSLPSLLT | 
    1200:
    RLEQMPDYSI | FRGYIIHYNL | ASAIEAADAY | TVFVPNNEAI | ESYIREKKAT | 
    1250:
    SLKEDILQYH | VVLGEKLLRN | DLHNGMHRET | MLGFSYLLAF | FLHNDQLYVN | 
    1300:
    EAPINYTNVA | TDKGVIHGLE | KVLEIKKNRC | DNNDTIIVRG | KCGKCSQQTL | 
    1350:
    CPLETKPLSE | TRKCIYSVYF | MGKRSIFIGC | QLQCVRTIIT | SACCAGFFGP | 
    1400:
    QCQACPGKGQ | NVCSGNGFCL | DGVNGTGTCE | CEQGFNGTAC | ETCTEGKYGI | 
    1450:
    HCDQACSCVH | GRCNQGPSGD | GSCDCDVGWR | GVKCDSEITT | DNCNGTCHTS | 
    1500:
    ANCLLDPDGK | ASCKCAAGFQ | GNGTVCTAIN | ACEISNGGCS | AKADCKRTIP | 
    1550:
    GSRVCVCKAG | YTGDGIVCLE | INPCLENHGG | CDRHAECTQT | GPNQAVCNCL | 
    1600:
    PKYTGDGKVC | TLINVCLTNN | GGCSPFAFCN | HTEQDQRTCT | CKPDYTGDGI | 
    1650:
    VCRGSIHSEL | PKNPSTSQYF | FQLQEHAVQE | LAGPGPFTVF | VPSSDSFNSE | 
    1700:
    SKLKVWDKQG | LMSQILRYHV | VACQQLLLEN | LKVITSATTL | QGEPISISVS | 
    1750:
    QDTVLINKKA | KVLSSDIIST | NGVIHVIDTL | LSPQNLLITP | KGASGRVLLN | 
    1800:
    LTTVAANHGY | TKFSKLIQDS | GLLKVITDPM | HTPVTLFWPT | DKALQALPQE | 
    1850:
    QQDFLFNEDN | KDKLKAYLKF | HVIRDTMALA | SDLPRSASWK | TLQGSELSVR | 
    1900:
    CGTGSDVGEL | FLNGQMCRII | QRRLLFDGGV | AYGIDCLLMD | PTEGGRCDTF | 
    1950:
    TTFNIPGECG | SCFSTPRCPL | QSKPKGVRKK | CIYNPLPFRR | DVEGCQNLCT | 
    2000:
    LVVHVPRCCS | GYFMPDCQAC | PGGPDTPCNN | RGMCYDQYKP | TGQCQCHTGF | 
    2050:
    NGTACELCLP | GRFGPDCQPC | GCSEHGQCDE | GITGSGQCLC | EAGWTGRFCD | 
    2100:
    APTVVIPVCI | PACSMHATCM | ENNTCVCNLN | YEGDGITCTV | VDFCKQNNGG | 
    2150:
    CAKVAKCSQK | GTQVSCSCQK | GYKGDGHSCT | EIDPCANGVN | GGCHEHATCR | 
    2200:
    MTGPGKQKCE | CKSHYVGDGR | DCEPEQLPLD | RCLQDNGQCH | PDANCVDLHF | 
    2250:
    QDTTVGVFHL | RSPLGQYKLT | FDKAKEACAK | EAASIATYNQ | LSYAQKAKYH | 
    2300:
    LCSAGWLESG | RVAYPTIYAS | KKCANIVGIV | DYGTRTNKSE | MWDVFCYRMK | 
    2350:
    DVNCTCKAGY | VGDGFSCNGN | LLQVLMSFPS | LTNFLTEVLV | FSRSSAQGRA | 
    2400:
    FLKHLTDLSI | SGTLFVPQNS | GLPKNKSLSG | RDIEHHLTNV | NVSFYDDLVN | 
    2450:
    GTVLKTRLGS | QLLITSSQDQ | LHQEARFVDG | RAILQWDIIA | SNGVLHIISE | 
    2500:
    PLKAPPTAAT | AAHSGLGTGI | FCAVVLVTGA | IALAAYSYFR | LNQRTTGFRR | 
    2550:
    FESEDDIDAL | AFGKQQPESI | TNPLYETSTP | AAPEPSCDPF | TDSGERELEN | 
    2559:
    SDPLGALRS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Stabilin-2
    Cat.:
    E0466r
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Stabilin-2
    Cat.:
    E0466h
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Stabilin-2
    Cat.:
    E0466m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Stabilin-2
    Cat.:
    U0466r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Stabilin-2
    Cat.:
    U0466h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Stabilin-2
    Cat.:
    U0466m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Stabilin-2
    Cat.:
    P0466Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Stabilin-2
    Cat.:
    P0466Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Stabilin-2
    Cat.:
    P0466Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Stabilin-2
    Monoclonal Antibody for Mouse Stabilin-2
    Monoclonal Antibody for Mouse Stabilin-2
    Protein for Mouse Stabilin-2
    Protein for Mouse Stabilin-2
    Protein for Mouse Stabilin-2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues."
      Politz O. , Gratchev A. , McCourt P.A.G. , Schledzewski K. , Guillot P. , Johansson S. , Svineng G. , Franke P. , Kannicht C. , Kzhyshkowska J. , Longati P. , Velten F.W. , Johansson S. , Goerdt S.
      Biochem. J.362:155-164(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
      tissue: Liver.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1666-2559
      strain: C57BL/6J.
      tissue: Diencephalon.
    3. 3.
      "FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products."
      Tamura Y. , Adachi H. , Osuga J. , Ohashi K. , Yahagi N. , Sekiya M. , Okazaki H. , Tomita S. , Iizuka Y. , Shimano H. , Nagai R. , Kimura S. , Tsujimoto M. , Ishibashi S.
      J. Biol. Chem.278:12613-12617(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    4. 4.
      "Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces."
      Falkowski M. , Schledzewski K. , Hansen B. , Goerdt S.
      Histochem. Cell Biol.120:361-369(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    5. 5.
      "Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding."
      Hansen B. , Longati P. , Elvevold K. , Nedredal G.-I. , Schledzewski K. , Olsen R. , Falkowski M. , Kzhyshkowska J. , Carlsson F. , Johansson S. , Smedsroed B. , Goerdt S. , Johansson S. , McCourt P.
      Exp. Cell Res.303:160-173(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CLATHRIN AND AP2;SUBCELLULAR LOCATION
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2503;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    7. 7.
      "Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment."
      Park S.Y. , Kang K.B. , Thapa N. , Kim S.Y. , Lee S.J. , Kim I.S.
      J. Biol. Chem.283:10593-10600(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GULP1
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